Unraveling the secrets of regulating mitochondrial DNA replication.

TitleUnraveling the secrets of regulating mitochondrial DNA replication.
Publication TypeJournal Article
Year of Publication2009
AuthorsKlingbeil MM, Shapiro TA
JournalMol Cell
Volume35
Issue4
Pagination398-400
Date Published2009 Aug 28
ISSN1097-4164
KeywordsAnimals, DNA Helicases, DNA Replication, DNA, Kinetoplast, DNA, Mitochondrial, DNA, Protozoan, Gene Expression Regulation, Mutation, Peptide Hydrolases, Protozoan Proteins, Time Factors, Trypanosoma brucei brucei
Abstract

In this issue, Liu et al. (2009) report that maxicircle DNA copy number in trypanosomes is regulated by proteolysis of a helicase; the complex kinetoplast DNA system yields a clear view of how mitochondrial DNA replication can be regulated.

DOI10.1016/j.molcel.2009.08.007
Alternate JournalMol. Cell
PubMed ID19716784